gestate - Generalised Survival Trial Assessment Tool Environment
Provides tools to assist planning and monitoring of
time-to-event trials under complicated censoring assumptions
and/or non-proportional hazards. There are three main
components: The first is analytic calculation of predicted
time-to-event trial properties, providing estimates of expected
hazard ratio, event numbers and power under different analysis
methods. The second is simulation, allowing stochastic
estimation of these same properties. Thirdly, it provides
parametric event prediction using blinded trial data, including
creation of prediction intervals. Methods are based upon
numerical integration and a flexible object-orientated
structure for defining event, censoring and recruitment
distributions (Curves).